VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
Identifieur interne : 002127 ( Main/Exploration ); précédent : 002126; suivant : 002128VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
Auteurs : Yang Li [États-Unis] ; Fan Zhang [États-Unis] ; Nobuo Nagai [Japon] ; Zhongshu Tang [États-Unis] ; Shuihua Zhang [États-Unis] ; Pierre Scotney [Australie] ; Johan Lennartsson [Suède] ; Chaoyong Zhu [États-Unis] ; Yi Qu [États-Unis] ; Changge Fang [États-Unis] ; Jianyuan Hua [États-Unis] ; Osamu Matsuo [Japon] ; Guo-Hua Fong [États-Unis] ; Hao Ding [Canada] ; Yihai Cao [Suède] ; Kevin G. Becker [États-Unis] ; Andrew Nash [Australie] ; Carl-Henrik Heldin [Suède] ; Xuri Li [États-Unis]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2008.
Abstract
Despite its early discovery and high sequence homology to the other VEGF family members, the biological functions of VEGF-B remain poorly understood. We revealed here a novel function for VEGF-B as a potent inhibitor of apoptosis. Using gene expression profiling of mouse primary aortic smooth muscle cells, and confirming the results by real-time PCR using mouse and rat cell lines, we showed that VEGF-B inhibited the expression of genes encoding the proapoptotic BH3-only proteins and other apoptosis- and cell death–related proteins, including p53 and members of the caspase family, via activation of VEGFR-1. Consistent with this, VEGF-B treatment rescued neurons from apoptosis in the retina and brain in mouse models of ocular neurodegenerative disorders and stroke, respectively. Interestingly, VEGF-B treatment at the dose effective for neuronal survival did not cause retinal neovascularization, suggesting that VEGF-B is the first member of the VEGF family that has a potent antiapoptotic effect while lacking a general angiogenic activity. These findings indicate that VEGF-B may potentially offer a new therapeutic option for the treatment of neurodegenerative diseases.
Url:
DOI: 10.1172/JCI33673
PubMed: 18259607
PubMed Central: 2230661
Affiliations:
- Australie, Canada, Japon, Suède, États-Unis
- Connecticut, East Middle Sweden, Manitoba, Maryland, Svealand
- Stockholm, Uppsala, Winnipeg
- Université d'Uppsala, Université du Manitoba
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000582
- to stream Pmc, to step Curation: 000582
- to stream Pmc, to step Checkpoint: 000B44
- to stream Ncbi, to step Merge: 000872
- to stream Ncbi, to step Curation: 000872
- to stream Ncbi, to step Checkpoint: 000872
- to stream Main, to step Merge: 002310
- to stream Main, to step Curation: 002127
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats</title><author><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nagai, Nobuo" sort="Nagai, Nobuo" uniqKey="Nagai N" first="Nobuo" last="Nagai">Nobuo Nagai</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Zhongshu" sort="Tang, Zhongshu" uniqKey="Tang Z" first="Zhongshu" last="Tang">Zhongshu Tang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhang, Shuihua" sort="Zhang, Shuihua" uniqKey="Zhang S" first="Shuihua" last="Zhang">Shuihua Zhang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Scotney, Pierre" sort="Scotney, Pierre" uniqKey="Scotney P" first="Pierre" last="Scotney">Pierre Scotney</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">CSL Limited, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>CSL Limited, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Lennartsson, Johan" sort="Lennartsson, Johan" uniqKey="Lennartsson J" first="Johan" last="Lennartsson">Johan Lennartsson</name><affiliation wicri:level="4"><nlm:aff id="JCI33673">Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Zhu, Chaoyong" sort="Zhu, Chaoyong" uniqKey="Zhu C" first="Chaoyong" last="Zhu">Chaoyong Zhu</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Qu, Yi" sort="Qu, Yi" uniqKey="Qu Y" first="Yi" last="Qu">Yi Qu</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fang, Changge" sort="Fang, Changge" uniqKey="Fang C" first="Changge" last="Fang">Changge Fang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hua, Jianyuan" sort="Hua, Jianyuan" uniqKey="Hua J" first="Jianyuan" last="Hua">Jianyuan Hua</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Matsuo, Osamu" sort="Matsuo, Osamu" uniqKey="Matsuo O" first="Osamu" last="Matsuo">Osamu Matsuo</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Fong, Guo Hua" sort="Fong, Guo Hua" uniqKey="Fong G" first="Guo-Hua" last="Fong">Guo-Hua Fong</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Ding, Hao" sort="Ding, Hao" uniqKey="Ding H" first="Hao" last="Ding">Hao Ding</name><affiliation wicri:level="4"><nlm:aff id="JCI33673">Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation wicri:level="3"><nlm:aff id="JCI33673">Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Becker, Kevin G" sort="Becker, Kevin G" uniqKey="Becker K" first="Kevin G." last="Becker">Kevin G. Becker</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">TRIAD Technology Center, National Institute on Aging, NIH, Baltimore, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>TRIAD Technology Center, National Institute on Aging, NIH, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nash, Andrew" sort="Nash, Andrew" uniqKey="Nash A" first="Andrew" last="Nash">Andrew Nash</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">CSL Limited, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>CSL Limited, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Heldin, Carl Henrik" sort="Heldin, Carl Henrik" uniqKey="Heldin C" first="Carl-Henrik" last="Heldin">Carl-Henrik Heldin</name><affiliation wicri:level="4"><nlm:aff id="JCI33673">Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Li, Xuri" sort="Li, Xuri" uniqKey="Li X" first="Xuri" last="Li">Xuri Li</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18259607</idno><idno type="pmc">2230661</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230661</idno><idno type="RBID">PMC:2230661</idno><idno type="doi">10.1172/JCI33673</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000582</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000582</idno><idno type="wicri:Area/Pmc/Curation">000582</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000582</idno><idno type="wicri:Area/Pmc/Checkpoint">000B44</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B44</idno><idno type="wicri:Area/Ncbi/Merge">000872</idno><idno type="wicri:Area/Ncbi/Curation">000872</idno><idno type="wicri:Area/Ncbi/Checkpoint">000872</idno><idno type="wicri:doubleKey">0021-9738:2008:Li Y:vegf:b:inhibits</idno><idno type="wicri:Area/Main/Merge">002310</idno><idno type="wicri:Area/Main/Curation">002127</idno><idno type="wicri:Area/Main/Exploration">002127</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats</title><author><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nagai, Nobuo" sort="Nagai, Nobuo" uniqKey="Nagai N" first="Nobuo" last="Nagai">Nobuo Nagai</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Zhongshu" sort="Tang, Zhongshu" uniqKey="Tang Z" first="Zhongshu" last="Tang">Zhongshu Tang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhang, Shuihua" sort="Zhang, Shuihua" uniqKey="Zhang S" first="Shuihua" last="Zhang">Shuihua Zhang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Scotney, Pierre" sort="Scotney, Pierre" uniqKey="Scotney P" first="Pierre" last="Scotney">Pierre Scotney</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">CSL Limited, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>CSL Limited, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Lennartsson, Johan" sort="Lennartsson, Johan" uniqKey="Lennartsson J" first="Johan" last="Lennartsson">Johan Lennartsson</name><affiliation wicri:level="4"><nlm:aff id="JCI33673">Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Zhu, Chaoyong" sort="Zhu, Chaoyong" uniqKey="Zhu C" first="Chaoyong" last="Zhu">Chaoyong Zhu</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Qu, Yi" sort="Qu, Yi" uniqKey="Qu Y" first="Yi" last="Qu">Yi Qu</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fang, Changge" sort="Fang, Changge" uniqKey="Fang C" first="Changge" last="Fang">Changge Fang</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hua, Jianyuan" sort="Hua, Jianyuan" uniqKey="Hua J" first="Jianyuan" last="Hua">Jianyuan Hua</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Matsuo, Osamu" sort="Matsuo, Osamu" uniqKey="Matsuo O" first="Osamu" last="Matsuo">Osamu Matsuo</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Fong, Guo Hua" sort="Fong, Guo Hua" uniqKey="Fong G" first="Guo-Hua" last="Fong">Guo-Hua Fong</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Ding, Hao" sort="Ding, Hao" uniqKey="Ding H" first="Hao" last="Ding">Hao Ding</name><affiliation wicri:level="4"><nlm:aff id="JCI33673">Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation wicri:level="3"><nlm:aff id="JCI33673">Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Becker, Kevin G" sort="Becker, Kevin G" uniqKey="Becker K" first="Kevin G." last="Becker">Kevin G. Becker</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">TRIAD Technology Center, National Institute on Aging, NIH, Baltimore, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>TRIAD Technology Center, National Institute on Aging, NIH, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nash, Andrew" sort="Nash, Andrew" uniqKey="Nash A" first="Andrew" last="Nash">Andrew Nash</name><affiliation wicri:level="1"><nlm:aff id="JCI33673">CSL Limited, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>CSL Limited, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Heldin, Carl Henrik" sort="Heldin, Carl Henrik" uniqKey="Heldin C" first="Carl-Henrik" last="Heldin">Carl-Henrik Heldin</name><affiliation wicri:level="4"><nlm:aff id="JCI33673">Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Li, Xuri" sort="Li, Xuri" uniqKey="Li X" first="Xuri" last="Li">Xuri Li</name><affiliation wicri:level="2"><nlm:aff id="JCI33673">National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Despite its early discovery and high sequence homology to the other VEGF family members, the biological functions of VEGF-B remain poorly understood. We revealed here a novel function for VEGF-B as a potent inhibitor of apoptosis. Using gene expression profiling of mouse primary aortic smooth muscle cells, and confirming the results by real-time PCR using mouse and rat cell lines, we showed that VEGF-B inhibited the expression of genes encoding the proapoptotic BH3-only proteins and other apoptosis- and cell death–related proteins, including p53 and members of the caspase family, via activation of VEGFR-1. Consistent with this, VEGF-B treatment rescued neurons from apoptosis in the retina and brain in mouse models of ocular neurodegenerative disorders and stroke, respectively. Interestingly, VEGF-B treatment at the dose effective for neuronal survival did not cause retinal neovascularization, suggesting that VEGF-B is the first member of the VEGF family that has a potent antiapoptotic effect while lacking a general angiogenic activity. These findings indicate that VEGF-B may potentially offer a new therapeutic option for the treatment of neurodegenerative diseases.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Japon</li><li>Suède</li><li>États-Unis</li></country><region><li>Connecticut</li><li>East Middle Sweden</li><li>Manitoba</li><li>Maryland</li><li>Svealand</li></region><settlement><li>Stockholm</li><li>Uppsala</li><li>Winnipeg</li></settlement><orgName><li>Université d'Uppsala</li><li>Université du Manitoba</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name></region><name sortKey="Becker, Kevin G" sort="Becker, Kevin G" uniqKey="Becker K" first="Kevin G." last="Becker">Kevin G. Becker</name><name sortKey="Fang, Changge" sort="Fang, Changge" uniqKey="Fang C" first="Changge" last="Fang">Changge Fang</name><name sortKey="Fong, Guo Hua" sort="Fong, Guo Hua" uniqKey="Fong G" first="Guo-Hua" last="Fong">Guo-Hua Fong</name><name sortKey="Hua, Jianyuan" sort="Hua, Jianyuan" uniqKey="Hua J" first="Jianyuan" last="Hua">Jianyuan Hua</name><name sortKey="Li, Xuri" sort="Li, Xuri" uniqKey="Li X" first="Xuri" last="Li">Xuri Li</name><name sortKey="Qu, Yi" sort="Qu, Yi" uniqKey="Qu Y" first="Yi" last="Qu">Yi Qu</name><name sortKey="Tang, Zhongshu" sort="Tang, Zhongshu" uniqKey="Tang Z" first="Zhongshu" last="Tang">Zhongshu Tang</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><name sortKey="Zhang, Shuihua" sort="Zhang, Shuihua" uniqKey="Zhang S" first="Shuihua" last="Zhang">Shuihua Zhang</name><name sortKey="Zhu, Chaoyong" sort="Zhu, Chaoyong" uniqKey="Zhu C" first="Chaoyong" last="Zhu">Chaoyong Zhu</name></country><country name="Japon"><noRegion><name sortKey="Nagai, Nobuo" sort="Nagai, Nobuo" uniqKey="Nagai N" first="Nobuo" last="Nagai">Nobuo Nagai</name></noRegion><name sortKey="Matsuo, Osamu" sort="Matsuo, Osamu" uniqKey="Matsuo O" first="Osamu" last="Matsuo">Osamu Matsuo</name></country><country name="Australie"><noRegion><name sortKey="Scotney, Pierre" sort="Scotney, Pierre" uniqKey="Scotney P" first="Pierre" last="Scotney">Pierre Scotney</name></noRegion><name sortKey="Nash, Andrew" sort="Nash, Andrew" uniqKey="Nash A" first="Andrew" last="Nash">Andrew Nash</name></country><country name="Suède"><region name="Svealand"><name sortKey="Lennartsson, Johan" sort="Lennartsson, Johan" uniqKey="Lennartsson J" first="Johan" last="Lennartsson">Johan Lennartsson</name></region><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><name sortKey="Heldin, Carl Henrik" sort="Heldin, Carl Henrik" uniqKey="Heldin C" first="Carl-Henrik" last="Heldin">Carl-Henrik Heldin</name></country><country name="Canada"><region name="Manitoba"><name sortKey="Ding, Hao" sort="Ding, Hao" uniqKey="Ding H" first="Hao" last="Ding">Hao Ding</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002127 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002127 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2230661
|texte= VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18259607" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |